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This study was retained in the DCD analysis due to its rigorous methodology, with its larger sample size (227 participants) and extended 12-month follow-up period likely contributing to the observed differences in effect size

CED complex shifts from the CT complex to aggresomes CTIF was originally identified as a CT component 6

524,525 In the liver, insulin suppresses the gluconeogenic enzymes PEPCK and G6 Pase via the Akt and FOXO pathways, 526,527 but resistance impairs this process, increasing glucose output