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Remarkably, the TSS pathway is compensatively activated when the extracellular source of cystine is restricted or under extreme oxidative stress conditions

[7] Whether this chloride flow is depolarizing (makes the voltage across the cell's membrane less negative), shunting (has no effect on the cell's membrane potential), or inhibitory/hyperpolarizing (makes the cell's membrane more negative) depends on the direction of the flow of chloride

Rogol, J

The adaptor ASC has extracellular and prionoid activities that propagate inflammation

The precipitated proteins were collected by centrifugation at 14 000 x g for 10 min

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