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In contrast to healthy, differentiated cells, which rely on mitochondrial OXPHOS to generate energy, cancer cells rely on aerobic glycolysis

Gene therapies to upregulate specific isoforms and biomarkers for early detection are also on the horizon, aiming for personalized interventions

It's the forever strong

Another approach to study enzyme stability, and especially susceptibility to chaperone treatment, used a urea-induced unfolding technique of mutant -Gal A variants expressed in HEK cells, which is a valuable tool not only in the case of Fabry disease [56]