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Enucleation, a rate-limiting step of erythrocyte maturation, is tightly regulated via coordination of multiple transcription factors (FOXO3, E2F2, etc.), miRNAs (miR-30a, miR-191, miR-181a), cytoskeleton proteins (F-actin, dynein, tropomodulin, etc.), and kinases (p38 MAPK, p38 mitogen-activated protein kinase) [33]

Upregulation of NADPH oxidases in CKD creates signals to induce muscle insulin resistance [73]

Abundance, diversity and mobility potential of antibiotic resistance genes in pristine Tibetan Plateau soil as revealed by soil metagenomics

413,414 However, in a placebo-controlled AD trial, Curcumin C3 Complex failed to improve clinical or biochemical outcomes, likely because of poor bioavailability and rapid metabolism

J Pineal Res (2007) 42(1):2842

280,281 However, SIRT2 has dual functions: its knockdown can increase basal autophagy while preventing apoptosis during mitotic arrest, 282 whereas in renal podocytes, it suppresses autophagy and impairs proliferation