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The risk of Parkinson's disease in inflammatory bowel disease: a systematic review and meta-analysis

In female mice infected with CVB3, the infiltrating macrophages in the myocardium predominantly exhibit M2 polarization, which alleviates the severity of myocarditis by modulating the local cytokine environment and promoting the differentiation of regulatory T cells (243)

Rich lipofuscin granules have been observed in lymphocytes from aged mice, and it is known that lipofuscin may act as a danger signal, stimulating the release of pro-inflammatory chemokines and cytokines and activating macrophages, thereby leading to a chronic oxidative-inflammatory process 52

Singh NN, Howell MD, Androphy EJ, Singh RN

Sholl analysis, performed via the ImageJ plugin, automatically generated concentric circles with 10-m spacing from the nucleus (soma) to the farthest astrocytic process

We propose that dysbiosis promotes ferroptosis in ovarian granulosa cells through disrupted iron homeostasis, diminished production of protective microbial metabolites, and systemic inflammation, collectively contributing to the reproductive and metabolic disturbances in PCOS