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The network view showed the most significant relationships between perturbed biochemical pathways in PsA, for example, between glutathione, alanine metabolism, and glycine and serine metabolism via glutamate metabolism, as well as between glucose-alanine cycle and alanine metabolism via the transfer of acetyl groups into mitochondria (Fig

International Immunopharmacology

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Since GSTO1 knockdown has been known to result in increased protein glutathionylation 14 , glutathione depletion by CHAC1 could possibly contribute in restoring the glutathionylation balance