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doi: 10.1016/j.cell.2007.10.035

Kidney Excretion: The kidneys play an important role in filtering out urea and forming urine

This action of CHAC1, known as the blocker of NOTCH, effectively reduces the cell surface expression of the full-length NOTCH1 receptor, thus inhibiting the NOTCH1 signaling pathway and contributing to the suppression of T-ALL cell viability (Chang Soo et al., 2023)