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We validated these data in primary neurons and astrocytes by Q-PCR and immunoblotting (Fig

While the re-establishment of blood flow is vital to salvage ischaemic tissue, it also triggers abrupt calcium influx into cardiomyocytes, which were already primed by ionic imbalances during ischaemia [12]

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These findings suggest that research into the therapeutic modulation of FOXO4 activity, such as through the use of the synthetic peptide FOXO4-DRI, could provide insight into the heart's natural protective mechanisms and degenerative changes associated with aging

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