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Hepatomegaly Prognosis: Death in infancy or childhood Lab Serum: Lactic Acidosis Tissue biochemistry Selective reduction in oligomycin sensitive ATPase activity (18 to 33% of normal) Short half-life of ATPase subunit Reduced Proton leak in inner mitochondrial membrane Complex V (ATP synthase) deficiency (MC5DN1) 39 ATP synthase F1 complex assembly factor-2 (ATPAF2

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It is classified as primary (polycythemia vera, D45), secondary (reactive elevation from hypoxia, EPO excess, or other causes

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179 In PD, changes in immune cell function, particularly the accumulation of senescent T cells, significantly exacerbate the progression of the disease

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