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These results imply that supplementation of P-80 to wild-type worms does not merely give rise to accumulation of storage lipids (i.e., TAG), but also profoundly change the profile of membrane lipids such as the glycerophospholipids

Burns, J

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While these are considered safe in small amounts, a routine that involves multiple low-quality supplements can increase the livers "toxic load." The liver has to process these non-nutritive additives, which is why we emphasize the importance of clean, transparent formulations