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These effects were mediated by suppressing the Smad2/3 signaling pathway, a crucial regulator in fibrosis [19]

This process may help reduce hyperpigmentation due to scarring

Figure 4 All the DEGs were also shown in the format of scatter diagram and volcano plot (Additional Supplementary Figures 2, 3)

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Additionally, we detected a significant increase in insulin receptor (INSR) protein expression in the HFD-IF-KO mice compared to HFD-AL and HFD-IF groups (Fig