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Description

Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate

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o r g / l i c e n s e s / b y - n c - n d / 4

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This is likely a distinct pathway from PFKL-mediated suppression of PMA-induced NET formation, which operates by redirecting flow from the oxPPP to glycolysis 37 because HA-induced NET formation is not blocked by G6PD or NOX inhibitors

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The commonly found variants of this enzyme are P1173L and A2756G

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P.BianY

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