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Ionov Y, et al

doi: 10.1016/j.ctcp.2018.03.013

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The intestinal mucosa forms a critical interface between these microbes and the host: a single-cell epithelial layer with tight junctions that limit bacterial translocation, overlain by mucus and patrolled by immune cells [18]

Notably, supplementing the drinking water of these mice with the histone deacetylase inhibitor sodium butyrate delays premature cellular aging in these mutants and increases lifespan ( Histone H2B PTMs Associated With Lifespan Histone H2B monoubiquitination at lysine 123 in yeast and, correspondingly, lysine 120 in vertebrates is required for the trimethylation of both H3K4 and H3K79 (Nakanishi et al., 2009)