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In addition , pharmacological testing revealed that AC caused a dose-dependent reduction in systolic, diastolic, and mean arterial blood pressure in pentothal-anesthetized normotensive rats (Ahmad et al

The reduced control was measured directly

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But to go back to, if the perspective was you might need more thiamine, so you should try adding some nutritional yeast to the dishes that you want to impart a cheesy flavor to, which is what nutritional yeast tastes like, because nutritional yeast is really high in thiamine, then that probably wouldnt have happened because the dose would have been a lot lower