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Sci Rep 8 , 2831 (2018)

Extensive evidence highlights its key safety characteristics: No genotoxic or mutagenic activity: The JofEM study [2] on AOD 9604 reported no genotoxic effects in rats and cynomolgus monkeys during Ames, chromosomal aberration, and bone micronucleus assays

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Np63 mediates sulforaphane suppressed colorectal cancer stem cell properties through transcriptional regulation of Nanog/Oct4/Sox2

However, the lack of targeting of PLGA NPs and the wide variation in brain uptake efficiency by different routes of administration limit the therapeutic efficacy of loaded drugs

Indeed, weak densities that could be attributed to heparin were observed on top of two N domains of NK1 dimer, but cannot be modeled due to the low resolution