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doi: 10.2174/138920211796429736 3

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In response to systemic inflammatory factors (e.g., ROS, LPS-mediated TLR4 signaling, TNF-), G6PD undergoes compensatory upregulation in the endothelium (105)

Related studies have shown that a considerable proportion of patients with COPD have insufficient vitamin D levels (153), and vitamin D deficiency is associated with a decline in lung function and an increased risk of acute exacerbations of COPD (138, 154), which may be related to a decrease in glutathione peroxidase 4 (GPX4) and an increase in iron parameters (155)

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