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Looking to the future, the ideal intervertebral disc repair material should have the following characteristics: good mechanical properties to restore intervertebral space height and bear physiological loads

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Studies have shown that senescent cells and the VDR gene expression interference system can reduce cell viability, proliferation and bone differentiation ability

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In this embodiment, contacting means bringing the compound and optionally one or more additional therapeutic agents into close proximity to the cells in need of such modulation

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