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A controlled human study did not find a significant effect on stimulated ACTH or cortisol release

Short answer: It appears tolerable in very limited early human data, but there is not enough evidence to call it safe for general use

Purity and a certificate of analysis matter more here than the lowest price on the page, because a clean sample is the starting point for any meaningful result

Its cognitive potential is inferred from TREK-1 knockout mouse phenotypes (enhanced memory) and from neurogenesis data rather than direct cognitive testing

Vitamin B12 deficiency can cause various severe health complications