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A follow-up blood test four to eight weeks after beginning supplementation confirms whether levels are improving

JCI Insight 5, e139640

[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Sonenberg N & Hinnebusch AG Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

2.7 Alteration of gut microbiota composition The mechanisms through which probiotics exert these effects are multifaceted and include competitive exclusion of pathogens, production of antimicrobial metabolites (e.g., bacteriocins and short-chain fatty acids), modulation of local pH, enhancement of mucosal barrier integrity, and immunomodulation (2, 33, 35)

Because patients with PD already show reduced levels of protective Trp derivatives, further restriction could exacerbate this deficit and undermine AhR-mediated signaling