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For instance, in mouse embryonic stem cells, targeted disruption of glucose-6-phosphate dehydrogenase, which is the rate-limiting enzyme in the pentose phosphate pathway, the predominant metabolic pathway for the generation of NADPH (a cofactor of GR), renders cells extremely sensitive to H 2 O 2 -induced cell death 34

In contrast, UC is primarily influenced by cytokines like IL-4, IL-5, IL-10, and IL-13 produced by Th2-type T cells

For instance, some PD patients take amine oxidase inhibitors or anticholinergics that alter gut motility and bacterial growth [172]

B., Song, Z

In acute situations, the critical loss of hepatocyte compromises liver functions and eventually leads to liver failure, and liver regeneration replenishes the lost hepatocytes to maintain liver functions