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Intratracheal instillation of BLM to establish a mouse model of pulmonary fibrosis is one of the most used methods to study the pathogenesis of pulmonary fibrosis

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Structure-based development led to the design of B-017, a cell-penetrable variant of the BNIP-3 peptide, which is a highly efficacious modulator of this axis with target specificity and a favourable safety profile and may thus be a treatment option for a range of pathological conditions

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