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The hepatic first-pass effect can be avoided to a great extent by use of sublingual tablets and transdermal preparations and to a lesser extent by use of rectal suppositories

Patil, Aonghus OLoughlin, Timothy OBrien Frontiers in Endocrinology.2014;[Epub] CrossRef Emerging roles of hematopoietic cells in the pathobiology of diabetic complications Hideto Kojima, Jongoh Kim, Lawrence Chan Trends in Endocrinology & Metabolism.2014

This finding is particularly relevant in the context of escalating global obesity rates and associated health challenges

Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, et al

[3] Le Roith D, Bondy C, Yakar S, Liu JL, Butler A

But, I extrapolated, there must be far more species of antibody than there are cells available