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Although melasma is a non-malignant skin disorder, however, if a proper, well-timed, and optimum therapeutic regimen is not considered, it can induce various psychological and emotional distress including feelings of frustration, unattractiveness, and embarrassment (Wu et al., 2021)

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-Driven Gene Transcription

Methods: We identified a MASLD cohort between 2007 and 2009 (baseline period), applying the validated algorithm (PMID: 30144434) to the VA EHR and selecting patients with at least one metabolic feature at baseline

Cell Metab 33:17011715.e1705 Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death

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