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Monitor IGF1 levels at baseline and periodically (every 12 months) to confirm response and adjust dosing if needed

At the time of writing, phase II clinical trials are underway for some of these agents with negative results in INVOKE-2 trial (van Lengerich et al., 2023

Furthermore, total iron levels and mRNA and protein levels of FTH1 was significantly increased in TGF-1-treated NRK-52E cells compared to controls (Figs

doi: 10.1016/j.jep.2025.119930 224 DengJWuZChenCZhaoZLiYSuZet al

The above doses are average recommendations

Some experts recommend a trial of ursodeoxycholic acid (UDCA), a bile acid occurring naturally in small quantities in humans, as it has been shown to lower elevated liver enzyme numbers in patients with PSC and has proven effective in other cholestatic liver diseases