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The growth-promoting activity of HGH is mediated by IGF-1, which: Promotes muscle protein synthesis Inhibits protein breakdown Promotes bone development Increases bone density Promotes glucose uptake HGH is also lipolytic and: Stimulates the oxidation of fat, especially during periods of fasting Promotes insulin resistance The net outcome of HGH administration when it is used for the treatment of GH deficiency is enhanced growth with a notable drawback of insulin resistance

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