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Additionally, induced ERCs have been shown to differentiate into functional hepatocyte-like cells ( 3.1.4 Expanded therapeutic potential of MenSCs through multilineage differentiation Multilineage-differentiating stress-enduring (Muse) cells, derived from mesenchymal stem cells (MSCs), are pluripotent cells with the capacity to differentiate into all three germ layers and exhibit enhanced resistance to environmental stress (Li et al., 2013a), and preferentially home to sites of tissue injury (Kushida et al., 2018), thereby overcoming the limitations associated with conventional MSCs in clinical applications

Beyond histones, non-histone lactylation expands functional repertoires through lactyl-CoA-independent mechanisms

doi: 10.1038/s41580-020-00313-x

This has the added effect of making the cheekbones more prominent

Q., Travagli, R

When exposed to bile acids, ME-3 survived for 24 hours without significant loss of live bacteria. Thus, Lactobacillus fermentum ME-3 can tolerate exposure to harsh acidity in the stomach as well as exposure to bile acids in the small intestine