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However, ChAT activity did not correlate with circulating choline or acetylcholine (ACh) concentration, which suggests additional regulatory mechanisms

In older patients, B12 deficiency can mimic early dementia, and correcting the deficiency sometimes produces noticeable improvement in cognitive function

36 JiangP.DuW.WangX.MancusoA.GaoX.WuM.et al (2011)

As we age, production of both proteins declines significantly while degradation accelerates