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Anhedonia is a classic feature of MDD, and MDD is also accompanied by a lack of drive, sleep issues, cognitive challenges, and emotional symptoms such as guilt

[PMC free article: PMC1559781] [PubMed: 16891413] 179

Crucially, MAGI3-mediated suppression of Wnt signaling sensitizes ccRCC to mTOR inhibitors

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Moreover, these protective effects occur with minimal cytotoxicity toward the normal cells, which supports its therapeutic properties in the neurodegenerative conditions such as Parkinsons and Alzheimers disease (AD) [16]

Alterations in gut microbiota can disrupt neurotransmitter homeostasis, particularly affecting serotonin (5-HT), norepinephrine (NE), and dopamine (DA) systems that are dysregulated in PTSD (Zhou et al., 2020)