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In SURMOUNT-2, the mean WL was up to 15.7% with tirzepatide 15 mg compared to 3.3% WL with placebo at 72 weeks for people with obesity and T2D [47]

Osteopontin has been shown to promote platinum resistance by enhancing stemness, activating the PI3K/AKT signaling pathway, and upregulating ABC transporter expression, thereby increasing drug efflux and reducing intracellular platinum accumulation [130]

Alcohol makes this even harder

The production of the oxidized form of GSH (GSSG) requires a cysteine residue which at physiological pH is present as a thiolate form

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma

The STEP 5 trial extended the observation period