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Wrinkle improvement is gradual and cumulative

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Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

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Weeks 5 through 8 at 0.5mg: 2.0mg total

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Statistical analysis and data graphing were performed using IBM SPSS 26.0, GraphPad Prism 8.0.1, and R 4.3.2

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Exp Biol Med 49 , 548553 (1942)

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