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Amylin receptor activation in the area postrema and lateral parabrachial nucleus reduces the rewarding value of food, decreases meal size, and promotes earlier satiation

KrattenmacherJCasalPDutkiewiczJHuchardESandersETreichNet al

Cerebral amyloid angiopathy and blood-brain barrier dysfunction

Some modulate GABA receptors

SallisRYoungDRTartofSYSallisJFSallJLiQet al

Key Takeaways Responsible prescribing and use of opioids, along with increased awareness of their risks, are essential to address the complex challenges associated with these medications