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Indeed, this is in line with previous findings suggesting that mtDNA replication and degradation occurs at random in mammalian cells, and that mtDNA turnover rates are high 28,29

However, as fibrosis is a complex pathological event, ultimately resolving this complex pathology will require a multi-pronged approach that moves far beyond single-target drugs

Meanwhile, as we discussed in this review, synaptic pathology is closely related to mitochondrial dysfunction in ASD

Melanouri EM, Diamantis I, Dedousi M, Dalaka E, Antonopoulou P, Papanikolaou S, Diamantopoulou P (2025) Pleurotus ostreatus : nutritional enhancement and antioxidant activity improvement through cultivation on spent mushroom substrate and roots of leafy vegetables

Rats were purchased from SIPHAT Company (central pharmacy of Tunisia)

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