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Platinum-based chemotherapy for variant castrate-resistant prostate cancer

30 There is conflicting data in the literature regarding the use of oral zinc supplementation in the treatment of acne

Yoshida T, Sun G, Pi J, Li X, Li B, Yamauchi H

Multivariate analysis revealed some predictive factors of 90 th -day poor clinical outcomes, including older age (OR 1.12, p = 0.007), male sex (OR 14.56, p = 0.023), predominant hemisphere lesion (OR12.30, p = 0.026), increased NIHSS of 2 points (OR 34.47, p = 0.006), and large artery atherosclerosis classification (OR 13.08, p = 0.016)

In contrast, DEDTC is a very strong acid ( pK a = 3.37), which would lead to a greater concentration of the active nucleophilic species at physiological pH (faster reaction rate), but would also yield less stable, more reversible adducts (thermodynamically unfavorable)

Cystathionine produced through transsulfuration is transformed to cysteine of which is oxidized to cysteine sulfinate by the rate limiting enzyme of taurine synthesis cysteine dioxygenase (CDO)