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L-methylmalonyl-CoA to Succinyl-CoA Conversion: Methylcobalamin is also a coenzyme for the enzyme methylmalonyl-CoA mutase

Potential Benefits & Side Effects Observations from preclinical and early clinical literature

Unlike NAD+ precursors that work downstream, 5-Amino-1MQ acts upstream by blocking NNMTs consumption of S-adenosyl methionine (SAM), resulting in elevated intracellular NAD+ and SAM levels without requiring direct nucleotide supplementation

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