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While promising, a multi-target strategy must also consider the potential risks associated with simultaneous targeting, particularly regarding its effects on normal tissue homeostasis

70 Notably, organotypic hippocampal slice cultures with ferroptosis-specific inhibitors were shown to prevent neuronal death and decrease hemoglobin-induced iron accumulation, suggesting a pathogenic role of ferroptosis in intracerebral hemorrhage

This poses many ethical questions about the ability of these people to provide true informed consent based on the many socioeconomic factors that drive this specific population to participate in these trials

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