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More and more studies have found that oxidative stress injury is involved in the pathological process of cognitive dysfunction in schizophrenia patients ( Oxidative stress and schizophrenia treatment Oxidative stress is amenable to early intervention and treatment, and there is a large therapeutic potential in this area

Melatonin lowers the activity and expression of proMMP-9, which has anti-inflammatory effects and lessens the damage caused by peritoneal endometriosis in mice (139)

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7.1 Anti-inflammatory therapies to lower systemic inflammation Systemic inflammation is a critical mediator in the pathophysiology of BBB disruption and cognitive dysfunction following intestinal I/R injury (Wei et al., 2021)