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60 mM for coronary) and endothelial integrity was confirmed by 50% relaxation to acetylcholine (10 M) in arteries contracted with U46619 (concentration to achieve 7080% of maximal KCl response)

Ojha, M

doi: 10.3389/fphar.2014.00260 Received 09 July 2014 Accepted 08 November 2014 Published 27 November 2014 Volume 5 - 2014 Edited by Alfonso Pompella, Universit di Pisa, Italy Reviewed by Salvatore Salomone, Catania University, Italy

Topical evidence for skin improvement is strong at the mechanism level (collagen, elastin, GAG synthesis upregulation in fibroblasts) and moderate at the human cosmetic-trial level (Leyden 2002 conference abstract