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Currently, it is widely used as a bioactive additive in the food industry, for example, in the processing of flour-based products, meat, fish, dairy products, and infant foods, and it is also extensively applied in the health supplement industry

The TRAVERSE trial, the first large randomized controlled study on testosterone replacement therapy, demonstrated that modest testosterone doses did not increase cardiovascular event risk in men aged 45-80

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At the molecular level, elevated circulating free fatty acids and aberrant cerebral lipid accumulation directly induce cerebrovascular endothelial dysfunction, ultimately compromising BBB integrity (82, 83)

2019;52:e12627

also based on the Healthy Eating Plate) found that those who changed their eating behaviours had a statistically significant reduction in monthly migraine days (from 10 to less than 6) and a non-significant decrease in monthly painkiller intake (from approximately 12 to 8), with reductions in total carbohydrate, and red and processed meat consumption appearing to have the most pronounced benefit