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Total MDA were measured using an MDA assay kit (TBA method, A003-1-2) purchased from Jiancheng (Nanjing, China)

A comparative pharmacokinetic evaluation of a bioavailable curcumin formulation Curene with curcumin formulation containing turmeric volatile oil and standard curcuminoids 95% in healthy human subjects

Nrf2 under physiologic conditions exists as a cytoplasmic protein bound to Kelch-like ECH-associated protein 1 (Keap1), keeping Nrf2 ubiquitinated for lysosomal degradation (Itoh et al., 1999

Normally highly expressed in the heart, Parkin degrades ACSL4 via ubiquitination, thereby inhibiting the production of PL-PUFAs and suppressing ferroptosis in cardiomyocytes

however, the reaction rate constants and the stability of the formed complexes are low

Instead, it is a desperate, compensatory mechanism