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Aging (Albany NY) 15 (20), 1154611553

2020;12:eaay1809

doi: 10.1128/AEM.02288-17

Physical exercise serves as a powerful epigenetic modulator, with the capacity to transform the skeletal muscle epigenome through ephemeral alterations in DNA methylation, nuclear export of HDACs, and reprogramming of miRNAs, thereby augmenting oxidative metabolism and regenerative potential (145)