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Description

A higher VOmax indicates more efficient oxygen utilization during exercise, which is commonly associated with better cardiorespiratory fitness

PMID 1731620

Optimal exposure windows, dose scheduling, and the potential for hormetic effects or long-term consequences are poorly defined, impeding the rational design of exercise mimetic administration strategies

Discussion This study attempted to resolve monocrotaline-induced pulmonary arterial hypertension in rats (i.e., initial pulmonary vascular endothelial damage, pulmonary arterial hypertension, RV hypertrophy, and fatality) (reviewed [15,16]), from the viewpoint of stomach cytoprotection (i.e., in the damaged rat stomach, rapid endothelium maintenance is the key for a pleiotropic beneficial effect) (reviewed [4,5,6])