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doi: 10.1016/j.freeradbiomed.2009.02.006 164 CiccaroneFTagliatestaSCaiafaPZampieriM

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Serious adverse events were uncommon in these trials, but rare outcomes and longer-term cardiovascular, renal, or oncologic risks require ongoing surveillance beyond trial lengths

Quality of life and physical function, gauged by the Impact of Weight on Quality of Life-Lite Clinical Trials (IWQOL-Lite-CT) and the 36-Item Short-Form Health Survey (SF-36), improved more with the combination therapy

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