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This enzyme is inducible, meaning that it is not normally detected in most tissues, but its production can increase in response to certain stimuli, such as inflammation [237]

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There is a great deal of evidence suggesting that DNA methylation defects are associated with ASDs, and the role of the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism may contribute to epigenetic mechanisms that modify complex gene expression, thus causing autism

Additionally, hospital pharmacies frequently substitute medications with generics or follow in-house standard operating procedures that prioritize specific drugs over others such that the medication administered to patients in the MIMIC-IV dataset might not necessarily always follow objective standards