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Hexarelin does this through a calcium/PKC cascade while blunting somatostatin's inhibitory signal, and Ipamorelin is considered more selective because it does not meaningfully raise cortisol or prolactin alongside GH

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doi:10.1016/j.clinthera.2011.05.088

40 Moreover, occludin-null males appeared infertile and did not produce litters when crossed with the wild-type (WT) females