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Recent studies have shown that synthetic monoclonal antibodies specific for SLC1A5 (i.e., KM4008, KM4012, and KM4018) are an effective therapeutic option for suppressing glutamine-dependent growth of CRC cells, but their efficacy in other cancer cells remains unclear 88

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Diacylglycerol lipase (DAG lipase) is responsible for the synthesis of 2-AG, and N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) is the key enzyme for the synthesis of anandamide