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meningitidis Within a genus such as Neisseria , characterized by notable genomic plasticity and consequent genetic heterogeneity, a key point of concern is the emergence of species potentially pathogenic for humans and other animals

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Studies have confirmed that 20(R)-ginsenoside Rg3 can significantly reduce the expression of Ki-67 and PCNA, inhibit cell migration, decrease the expression of collagen I/III, downregulate pro-fibrotic genes such as fibronectin and connective tissue growth factor (CTGF), upregulate anti-fibrotic genes such as TGF- 3, and increase the ratios of matrix metalloproteinase (MMP) 2/tissue inhibitor of metalloproteinase (TIMP) 1 and MMP9/TIMP1 by regulating the ERK and TGF- /Smad pathways ( Persistent infiltration of inflammatory cells, such as neutrophils, macrophages, and lymphocytes, in scar tissue releases IL-6, IL-1, and tumor necrosis factor- (TNF-), which further stimulate fibroblast proliferation and collagen synthesis, forming an inflammation-fibrosis vicious cycle

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