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FoxO factors can also induce the expression of genes involved in antioxidant defense such as superoxide dismutase or catalase, or genes involved in anti-inflammatory responses, such as IL-10 or suppressor of cytokine signaling 3, thereby protecting against oxidative stress and inflammation induced by senescence (216)

SOD is synthesized in response to oxidative stress and acts as an antioxidant, but its elevation in intracellular conditions increases cell damage by a generation of H 2 O 2 34

J Biol Chem 267:80308034 Blass SC, Goost H, Burger C, Tolba RH, Stoffel-Wagner B, Stehle P, Ellinger S (2013) Extracellular micronutrient levels and pro-/antioxidant status in trauma patients with wound healing disorders: results of a cross-sectional study

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