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reported a dose-dependent increase in PT when NAC was added directly to blood plasma samples, though NAC dosing was significantly higher in this in vitro study (concentrations of 250, 500 or 1000 mg/l) than suggested dosing for perioperative pain [92]

8B, C and Supplementary Video 9)

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The vial should remain sealed when not in use, and all withdrawals should be performed using appropriate sterile laboratory technique

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doi:10.1016/0197-2456(89)90057-3