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However, in the context of elevated vitamin C uptake, high vitamin C can act as a pro-oxidant by reducing iron and promoting lipid peroxidation, GPX4 inactivation, and ferroptotic cell death 125

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Things that might lead to dose changes include how bad the deficiency was, if there are nerve symptoms, if theres ongoing trouble absorbing nutrients, and how each patient responds

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Therefore, the need for innovative therapeutic approaches is urgent, and in recent years, targeted or chemotherapeutic drug delivery approaches using nanoparticles have started to emerge