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Eur J Pharmacol (2000) 398:13946

A second enzyme, NADPH-cytochrome P 450 oxidoreductase, transfers electrons to the CYP where it can, in the presence of O 2 , oxidize xenobiotic substrates, many of which are hydrophobic and dissolved in the ER

It participates in rapid, non-genomic estrogen signaling by activating various protein kinase cascades such as protein kinase A (PKA), protein kinase C (PKC), and mitogen-activated protein kinase (MAPK) (cases have also been observed where GPER1 regulates the expression of specific genes, however, this is not its typical mode of action) [39, 50, 51]

Citric Acid : A central metabolite in the Krebs cycle, essential for energy production

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Mechanistically, GLP-1 carries out its various functions through a PKA-dependent signaling pathway, which plays a key role in regulating NF-B activation across multiple inflammatory conditions [113, 117,118,119,120]